Out of the major operating systems, Windows is probably by far my favorite to develop for[1] using Rust. windows-rs[2] is officially supported and is constantly being worked on and improved.
However, if I as an absolute Windows programming newbie with basic competency in Rust could pick up windows-rs and build a tiling window manager, I'm sure that people who are intimately familiar with the .NET and Windows development ecosystem could develop incredible things targeting Windows with Rust.
This is a hypothetical that only looks at what .NET but in Rust would look like, ecosystem aside