The relative lack of (touch) sensitivity and the more limited variation in timbre are immediately noticeable. One of the other qualities of a traditional piano that I instantly miss in even the best digital simulations is sympathetic vibration. Holding the sustain pedal down will not simply allow the notes to play longer. Other strings that freed up begin to vibrate as well. It produces an effect that - the last I checked - is not well emulated in a digital environment.
Reflective of the values of our age I guess. Small, relatively portable, low maintenance wins out in many other arenas. Why not music...