A sober, or an experienced trustworthy, tripsitter is almost a must. A
small amount of MDMA (especially if you're not familiar with it) before taking a psychedelic can be helpful as mentioned. Having some sedatives just handy just in case may itself lessen the probability of unpleasant effects.
Micro-dosing is mostly placebo. But a good idea is to start with small doses (check e.g. the "threshold limits" at Psychonaut Wiki), and maybe faster shorter acting substances like 2C-B or mushrooms rather than longer acting like LSD.
Also good to acknowledge that psychedelics just aren't very enjoyable experiences for many, and even for most they are rarely unambiguously good.