The one that I really miss is Macromedia Fireworks.
The perfect mix between vector editor + html editor + OOP.
And to think that it did all of that in the metadata of a binary format (png).
Nothing has come close.
Fireworks could have been Figma, it could have been the default platform every designer used. But Adobe didn't understand it, they saw it as a weird Photoshop competitor and shelved it.
The last few versions bundled with CS were clearly neglected maintenance releases. I finally stopped using my slowing rotting copy in about 2014 when I got a Mac with a retina screen and fireworks was stuck with a terrible pixel doubled ui. :-(
I still haven't found an acceptable replacement, choosing instead to design in-browser with CSS. Of course this means I can't make graphic heavy designs that I can slice and export with transparent PNGs, but we haven't cycled back to that sort of design yet so I'll be OK with minimalist crap for a while.
It was a sad day for me when it got bought and integrated into Dreamweaver.
I used to make a non-insignificant amount of rasterised computer “art” using fireworks, its discontinuance (and the fact that photoshop was not at all a replacement) killed that for me.