Don't let this stop you. Every. If you honestly think you have the skills for the job after reading the description, seek it out. Let them determine if you are right for the position.
Don't be the no in your life.
I feel like this is from the movie Yes, Man! That aside, I take your advice to heart. I don't want to be the no in my life. :)
In a search looking for that exact quote, I came up with only a few links. All from either comments I made previously or a blog post.
http://news.ycombinator.com/item?id=2504632
That was where I originally used it.
I was proud of it, mostly because it was short and to the point. I'm usually not short and to the point.
Anyways, in writing about this on my blog, I had a wonderful surprise happen.
http://www.jasonlotito.com/advice/sometimes-i-amaze-myself/
From his LinkedIn profile, I take it he never got/took the job. But, he seems to be doing well.
But yeah, I think it's good advice.
That's some wonderful advice - thanks for sharing!