Install and enable Hiya or similar for calls.
Adjust your notification settings for apps like Lyft, Uber, and Uber Eats. They like to spam notifications as ads.
For adblocking, 1Blocker and AdGuard work great.
For YouTube on mobile web, use Vinegar.
I am 99% protected from ads with this setup
For the remaining, use old.reddit.com.
For websites with annoying subscription popovers, use reader mode. This doesn't work everywhere but does in a lot of places.
After all this filtering, I have absolutely no interest in anything that gets through.