Cool, but seems unwise.

If you are smart enough to do this to PHP, then you are hopefully smart enough to know you should probably not be writing your large system in PHP. There are many better base languages, as opposed to one which has the consistency of perl combined with the string handling power of C (a mild exaggeration, but not by as much as I wish it were). PHP's main advantage is that it is installed everywhere and just works. This breaks that, and therefore renders PHP's main advantage moot.