It is tricky but possible. It is being done in the data center for certain hyperscalers. I wonder if Oxide Computer is doing it also, they mentioned a high voltage DC bus I think. https://epc-co.com/epc/about-epc/gan-talk-blog/post/14229/48...

19V is pretty standard in notebooks so 19-24V could probably be done with fairly little trouble. 48V would entail developing a whole new line of capacitors, inductors, power stages (transistors), and controllers.^1

^1: yes, of course, 48V compatible components exist for all of those. But the PC industry typically gets components developed for its specific requirements because it has the volume.