Nah.
- Normally, just deleting /nix gets you 95% of the way back to normal.
- If you want a bulletproof removal, the determinate systems Nix installer saves a file with a list of all the operations it made during installation so that it can be cleanly removed.
- If you want to stop home-manager from hooking into your shell without completely removing Nix, there's a separate uninstall command for that.