Certainly still an option. There's a long history of folks like that, the market for e.g. Mac apps was if anything helped by the launch of the Mac app store (some devs more than others, long story, ask them for the specifics). I could give you two dozen examples from my social circles but most of them would not appreciate the publicity.

That said: can I talk you out of it? I've done both, and from a business perspective doing it as a web app is a MUCH better option.

http://www.kalzumeus.com/2009/09/05/desktop-aps-versus-web-a...