does this answer your question? https://monster6502.com/

"The MOnSter 6502 runs at about 1/20th the speed of the original, thanks to the much larger capacitance of the design. The maximum reliable clock rate is around 50 kHz. The primary limit to the clock speed is the gate capacitance of the MOSFETs that we are using, which is much larger than the capacitance of the MOSFETs on an original 6502 die."