Having used HTMX and Unpoly with Django, for over 2 years now, I prefer using Unpoly more these days.

Unpoly feels just like Django, it is a more of a framework than a thin layer, but that means it comes with a lot of productive features built-in, albeit opinionated.

It covers 95% of the use-cases of a typical web app, with its layers and forms concepts. E.g. I love creating "subinteractions" with unpoly, where a complex process can be divided into smaller modal forms for creating the "related" objects of a model, which then updates the main form of the model itself. Unpoly makes these simple, and its documentation caters for exactly these scenarios.