No. Even though Mathematica is arguably meaningful. It's very popular with some scientists, and in many aspects it's a respectable piece of software.

A few years ago Sean Carroll was hosting him on his podcast. It was a bit surprising to me because Sean would never give a crackpot the time of the day, and Wolfram is borderline in crackpot territory IMHO, but not quite. He hasn't published anything meaningful in a scientific journal in a long time as far as I know.