I view JQuery as similar to C in some ways: It's been around forever, it's mature, and it works. It gives a good experience to get something up and running quickly: it's lightweight and simple.

But if you're working on bigger projects: It is possible, but have have to be very principled in how you use it, otherwise you're going to end up with either a massive spaghetti codebase and lots of edge cases in your app that breaks.

Alternatives like React and Rust may add more complexity upfront, but the improved structure and safety it gives has big benefits in all but the smallest projects.