If you take the time to split up your data into chunks you can avoid the GIL entirely with multiprocessing. Or by handing it off to a library that does it for you. just as long as they’re not using the same python objects.
For example, if I parse an XML document with ElementTree, as a quick experiment, parsing the document takes ~1 second and serializing all the elements names and attributes to JSON takes an additional ~0.5 seconds. Serializing the whole ElementTree object using pickle takes ~4 seconds. Serializing it as XML takes roughly as long as parsing it.
It also screws up C extensions that don't support fork and does not solve the problem of increasing TLS handshake/fanout in outbound requests by the number of cores.
The whole thing sucks in production.