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in short - yes. there is nothing stopping the JIT code from surviving across requests, as long as you keep the process alive.

php over fastcgi is a good example of how to reuse the same php process. I use http://php-fpm.org/ and nginx and it's great.

The issue is not dissimilar to using existing opcode caching.

As mentioned, there is the opcode cache. I'm also thinking about FastCGI setups, where PHP is running the whole time, just waiting to execute code requests.