I used to have very frequent pain episodes that would severely affect my ability to type on a keyboard, and now they are almost completely gone (and when I do get them, it's nowhere near as severe as it used to be).
That said, I still have a Model 100 (as the one depicted in the older pictures in the post) and the ergonomics are IMHO worth it, at least compared to some of the keyboards available, but in particular to builtin laptop keyboards (as you mention, everything is bad about laptops and I treat mine like a very portable desktop: if I need to be on the move, I take my keyboard and trackpad and use the laptop as a small display).
On top of that, the fact that it's programmable turned out to be much better than I had thought. My workflow is heavily customized now and I'm objectively a lot faster than I used to be before. The layers system on this keyboard takes a bit of getting used to (as does the layout itself) but, at least for me, once I got through the learning curve, it's so good I'm going to buy another one to have as a spare.