Remicade and Entyvio have both been heavily tested.

Remicade is available in (at least) these countries: - US - Japan - Europe - Turkey - Russia

Entyvio: - US - Europe - Canada - Japan - Australia

Biologics are the first line of defense for anything over mild IBD. The only effective treatment for above moderate that isn't a combination of other meds is Rinvoq. The small dose items like Azith and Pred are just for flare management, and aren't maintenance medications.