My nephew and I taught ourselves Netrunner by reading through the rulebook and it was tough. Fortunately we were at Dicetower East and there were plenty of folks who stopped by to ask if we needed help (so many people excited to see Netrunner lol).

Overall if you just run a few games you will pick it up as you think through the implications of rules. My main complaint is that the recommended starter decks hide several mechanics so you end up reading all these rules that dont even apply at first.