In 2008/2009, another engineer and myself built an ad-platform that received around 500M impressions per day, 5M clicks per day. And it wasn't just recording a tweet or publishing out to followers. We took the user input query, had to do some keyword/relevancy targeting, geofiltering, matching to advertisers and deliver back a large result set of adverts. All within 100ms.
Our platform was also apache, mod_php, memcached, mysql and rabbitmq. So definitely not the most optimal of platforms by any means. We had two colos with ~20 servers (dell r410s) at each facility.
Twitter just recently announced 400M tweets/day. I'm not trying to brag about my experiences, because looking back now we made numerous amateur mistakes, but just showing that Twitter's "scale" is a joke compared to everyday challenges at any large internet ad network.