>42M uniques last month.[0] Are you really going to assert Twitter hasn't dealt with amazing or challenging hurdles in getting this far?
[0] http://siteanalytics.compete.com/twitter.com/
EDIT: this ignores that twitter.com is not the only Twitter client--they served 15B (!!) requests/day (!!!) as of a year ago.
Not to mention metadata, instrumentation for services, logging, DB backups, and managing configuration of all of those distributed resources. Are we still talking about the ease of 160B?
http://www.readwriteweb.com/hack/2011/07/twitter-serves-more...