Yes. In my opinion, it's clearly been a wasted effort to try to convince the rest of the country those rights are important. They need to be defended where they can, and the states that defend them need to separate themselves more and more from their parent country. Secession is silly, at least today. If what you're saying comes to pass—and it could even without what I'm suggesting—then at that point secession is the only correct answer.

Either way, it doesn't make sense to spend effort where it's not making a difference.

EDIT: Another part of this idea that I struggle with, is that we shouldn't ask people who aren't accepted to stay in places where they aren't accepted. They deserve rights. They should go to places where they can get them, and we should get them out of the places that don't respect them. And doing that, which I think is the moral thing to do, leads to what you're describing.