This array is a bit long-in-the-tooth and only has 192GB of RAM, but a bit over 40TB of net storage, which would be a 200GB dedup table size using the back-of-the-envelope estimate of 5GB/TB.

A more precise calculation on my actual data shows that today's data would allow the dedup table to fit in RAM, but if I ever want to actually use most of the 40TB of storage, I'd need more RAM. I've had a ZFS system swap dedup to disk before, and the performance dropped to approximately zero; fixing it was a PITA, so I'm not doing that anytime soon.