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Meta-analyses are a cool way to perform a garbage in, garbage out exercise.

What’s the evidence that the data going in is garbage? We already ascertained most of it is GRADE quality moderate.

I don’t research the topic for a living, so I don’t know — I’ve read none of the studies.

If the conclusion that comes out of the other end of the pipeline is that we should avoid eating the things we’ve eaten for millions of years, it’s fair to say what went in might have been based on false premises.

Why? Evolution doesn’t select for longevity, it selects for reproductive fitness. We have no reason to believe ancestral foods are more longevity promoting than novel ones, and antagonistic pleiotropy would suggest that all else held equal, ancestral foods are less healthy.

Heck, water treatment plants are novel compared to the pathogen-laced water we’ve been ancestrally consuming, but I doubt you eschew tap water for puddle water.

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