Of course in PoE2 it's used in full 3d.
The benefit of this approach is that you get global illumination with a constant cost for the entire scene and because it doesn't use any temporal acculation, it has zero latency as well.
This means you can rely on it as the lighting for fast effects. For example: https://www.youtube.com/watch?v=p1SvodIDz6E
There is no traditional "lighting" added to these two effects. The light on the nearby surfaces is indirect light from the GI solution that you get for free by just spawning the particles. That means all effects just naturally emit light with no extra work from artists.
On my GPU (which is admittedly a 4090) the GI solution runs in 0.8ms for a 4k scene in "High" quality. This is exactly what it will always cost, no matter what scene you choose.