This depends on the threat model. Having 2FA in the PW manager defends against someone phishing the password and database leaks on the server side, which are the most common in my threat model. But note that if they can phish your pw, they can probably phish your 2FA as well.

It does obviously not protect against the scenario where someone is breaking into your password vault.

I tend to enable 2FA but conveniently save the token in the PW manager for relatively low equity stuff, just to make it less enticing for an attacker, but use hardware FIDO for everything actually important.