So, given this BMJ-published research, why can researchers in the article's paper get away with claiming that flu vaccines are more effective than any other option (including vitamin D supplementation) when the research suggests otherwise?
So, given this BMJ-published research, why can researchers in the article's paper get away with claiming that flu vaccines are more effective than any other option (including vitamin D supplementation) when the research suggests otherwise?
What is the prevalence of <10 mg/dl Vitamin D deficiency in population? (Serious question.)
Obviously it depends on which "population" you're talking about, but it's pretty common. Insufficiency is also relevant and should be avoided if possible. The NIH estimates perhaps 1 billion global cases of deficiency (including "subclinical deficiency") and "50% of the population" (so ~4 billion) cases of insufficiency. [3] Prevalence unsurprisingly varies by sun exposure (climate and lifestyle) and absorption (i.e., "skin melanin content" as [3] puts it), and also by age.
Vitamin D supplements are quite cheap. I currently take 4000 IU/day and have taken as much as 10000 IU/day (for months at a time) in the past. Whatever the government might imply with its "RDA" or whatever, this should be completely safe, at least for anyone without very specific preexisting medical conditions - and the treatment for excess vitamin D levels (and the commonly associated hypercalcemia) is generally to just lay off for a while ([2], [4], [5]). Supplementation does work - I have blood tests to prove it. Regardless of any of the previous discourse about influenza or any other virus, it's probably a good idea for a very large fraction of the HN audience.
[1]: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessiona...
[2]: https://en.wikipedia.org/wiki/Vitamin_D
[3]: https://www.ncbi.nlm.nih.gov/books/NBK532266/
Re-read your own comment.
> Insufficiency is also relevant and should be avoided if possible
Sure. But that isn't relevant to the clinical question of reducing hospitalisation. About 40% of the American population is deficient to some degree; if we assume half are deficient to your threshold, that explains why vaccines are the most effective method: 40% (flu vaccine efficacy) of 100% (total population) is more than even 100% (assuming 100% efficacy of Vitamin D in preventing ILI hospitalisation, which is of course nonsense) of 20%.
> supplementation does work - I have blood tests to prove it
Nobody debates this. I take vitamin D.
> it's probably a good idea for a very large fraction of the HN audience
It's a good idea to talk to a doctor about it. Vitamin D is a hormone. Self administering large doses of hormones isn't good broad-spectrum advice.
My comment says ng/mL and nmol/L, and my sources agree. Your comment says mg/dl, which is different. A milligram of 1,25-dihydroxycholecalciferol is quite a lot; the nanogram range makes much more sense for this measurement. As you say, it's a hormone.
>Sure. But that isn't relevant to the clinical question of reducing hospitalisation.
I answered the question you asked, and I'm not the person you were originally responding to.
>Nobody debates this.
I'm glad that you don't, and that apparently nobody you know does. My personal experience differs.
>Self administering large doses of hormones isn't good broad-spectrum advice.
When I told my primary care physician about what I had done many years ago on the advice of a specialist, he told me quite directly that basically everyone around here should be supplementing vitamin D (particularly given how common it is to spend so much of our lives indoors). Toronto is not even at the 45th parallel. The doses in question are really not large, taken for example in the perspective of their measurable pharmacological effects.
Buddy, I copy pasted ng/mL from your comment. You're correct to have amended it into IUs. (EDIT: Never mind, nothing was amended.)
> he told me quite directly that basically everyone around here should be supplementing vitamin D
Sure. That's medical advice.
Yes, that's the point. My comment says ng/mL, because it should say ng/mL, because that is the correct unit for blood serum level (i.e., the thing that is tested in order to determine deficiency). In your first comment, you wrote mg/dl, which is incorrect. I did not "amend" anything to IUs. IUs are the dosage unit for supplementation. It's irrelevant to my initial correction.
>Sure. That's medical advice.
It's medical advice that explicitly indicated that the sort of personal request for medical advice you propose, is not actually necessary.
It still says "blood levels below 10 mg/dl" [1]!
If you don't understand the difference between A) the general health benefits of not being deficient in a vitamin/mineral/amino-acid/etc., and B) a _specific_ vaccine's effects against a _specific_ pathogen (or group of pathogens), I don't know what else to tell you.