There is an interview [0] with Hoeijmakers, who has championed the idea that the single root cause for both aging and cancer are faults in dna. Faults in dna prevent rna copies, aka _transcription stress_. One of his theses was that if faults in dna happen randomly, we would see aging the most in the largest genes. [1]
In his experiments [2] he was able to turn the knob of dna repair, also in humans, from "organism growth" to "organism survival".
Survival mode can be induced when confronted with food scarcity. If we can unravel the underlying mechanism, we should be able to enlarge our lifespan.
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0. https://www.nrc.nl/nieuws/2024/10/11/de-geneticus-die-gezond...
1. https://www.cell.com/action/showPdf?pii=S0168-9525%2824%2900...