Supercomputers, yes, but also genomics workloads. The vast majority of those workloads are effectively tied to one machine, since they don’t support cross-machine scaling, nor things like MPI.
If the latter, then maybe they can use multiple cores using things like OpenMP and the like to get some "free" scaling, but they could be made to work with MPI or across machines. However, if it's the former, more cores won't help them.