It's all guesswork until we start measuring the impact of interruptions in open plan offices vs. homes (which is going to vary with families).
I think it heavily depends on the person and type of work. I'm SWE and for most daily work I don't mind getting interrupted - I'm able to get back to work without a problem. It's only if I work on an extra difficult problem which requires very deep focus, I go somewhere quiet, but that's less than once a week.