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If you're talking about Effexor - famous for wicked brain zaps after only one missed dose - this could have more to do with its very short half life.

The S in SNRI stands for Serotonin, not Selective.

Today I Relearned: Selective Serotonin Reuptake Inhibitor (SSRI) != Serotonin Norepinephrine Reuptake Inhibitor (SNRI) != Selective Norepinephrine Reuptake inhibitor (sNRI)

There are also SDRI and SDNRI. D -> Dopamine.

Wow, I did not know that. Good to know.

The only time I got them was getting off a high dose of Strattera (atomoxetine), the rare non-stimulant ADHD medication, cold turkey.

got them after weaning of SNRIs, for about 1-2 years I had random brain zaps. Not that big of a deal per se, but definitely annoying.