Directly no not to my knowledge. Seems like a bit of an esoteric layout to be honest.
If you really want you could probably do it with two sets of interfaces but you'd still need an external device for wireguard. So same opnsense instance takes lan traffic and sends it to WG device, WG device sends it back to opnsense on a second set of interfaces and that goes out like a normal FW setup.
That way have opnsense both as perimeter device, and also benefitting from it as a LAN mgmt (DHCP etc).
To stick it all on one device you'd need virtualization I suspect. Can be done but wouldn't recommend.