It would be nice to dream of it happening sometime soon.
There is also a breakthrough therapy designation where the clinical evidence is solid enough to release the drug while they finish full trials but that’s only in exceptional cases.
FDA can fast track certain drugs, but it really needs to show amazing efficacy.
So sure we could speed things up by killing more people undergoing medical experiments. But the current approach of validating safety in humans then efficacy in humans is inherently serial. Further a lot more stuff is going into the pipeline than actually ends up working.
For context, I had been on Taltz before for psoriasis, and it worked very well. It seems like il17 inhibitors specifically are extremely targeted in what they affect.
In comparison, I was also on otezla at one point (tnf-a inhibitor) and it didnt work for me either, and the side effects were terrible.
Which was not the case with otezla. But tnfa blockers - yeah those are bad times.
In any case, good luck with your treatment!
My uncle has developed an autoimmune respiratory disease over twenty years ago, and I know he would give a whole lot to improve his condition.
(Please don’t downvote me because you don’t like the tone of that. Europe banned artificial food colors and Japan is using self-replicating RNA vaccines. There is a wide spectrum of risk tolerance and healthcare does not revolve around the USA)
Every few years, there is an scandal for illegal medicine, but I think most of the case it's about using industrial silicone in human cosmetic surgery or something as stupid like that, not cutting edge new drugs. Perhaps it's possible to get tourist-illegal-medicine, but I strongly advice against that.
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> Japan is using self-replicating RNA vaccines
Do you have a source for that? I can try to take a look. I suspect it's very bad journalism reporting.
Self-replicating RNA are just https://en.wikipedia.org/wiki/Viroid but they only survive in plants, not animals. If they make their own coating, they are retrovirus. Writing a retrovirus from scratch is too difficult, some vaccines use edited virus, where they add the interesting part but also remove another part to the virus can't reproduce outside the lab. And there are vaccines with "live" attenuated virus, like the oral polio vaccine, but they are more difficult to make.
Your characterization is inaccurate, of both the reporting and the technology
> The ARCT-154 study vaccine consists of sa-mRNA encapsulated in lipid nanoparticles. The RNA comprises a replicon based upon Venezuela equine encephalitis virus (VEEV) in which RNA coding for the VEEV structural proteins has been replaced with RNA coding for the full-length spike (S) glycoprotein of the SARS-CoV-2 D614G variant.
IIUC the RNA makes copies of itself inside the cell, but it does not get a capsule of proteins to travel and invade other cells. Is this correct?
(A few more details in https://en.wikipedia.org/wiki/MRNA_vaccine#Amplification but not enough for my curiosity level.)