It's so weird to say "unproven" when you're talking about a 1000 chemicals, because statistically the odds that they are all harmless seems negligible.
Also strange unfair exercise you're setting up -- that we can't be upset about chemicals if we aren't exercising?
How about instead -- the FDA finds a short list of proven safe food-grade wrappers, and we all pay the extra 1 cent per product to use those? I really cannot understand your mentality at all here.
250M plus people take these chemicals and the leaders in mortality and are all obesity related causes.
No mystery here. No deep research is needed.