My attitude used to be "who cares if there's a bit of random chemicals in your body, what's the worst that can happen?" but then I learned that tons of random chemicals happen to interact with our biology, like Xenoestrogens which are a whole class of chemicals (some in food packaging, like soda cans) that fit into estrogen receptors in the body and act like estrogens.
It's so weird to say "unproven" when you're talking about a 1000 chemicals, because statistically the odds that they are all harmless seems negligible.
Also strange unfair exercise you're setting up -- that we can't be upset about chemicals if we aren't exercising?
How about instead -- the FDA finds a short list of proven safe food-grade wrappers, and we all pay the extra 1 cent per product to use those? I really cannot understand your mentality at all here.
250M plus people take these chemicals and the leaders in mortality and are all obesity related causes.
No mystery here. No deep research is needed.