Interesting work. There are also clinical trials, recent and ongoing, looking at the effects of metformin on aging in humans, too, including the TAME trial[0].
I couldn't find the exact doses TAME is using, but some writeups point out that there's no effect on glucose levels beyond about 1,600mg per day.
[Citation Needed]
I am more forgetful now and a little bit more irritated at times, and I've heard this could be related to Metformin.
More like "the asshole! They're not called "Metfartmin" for nothing! If you want to live a long smelly life with no friends and certainly with no bed partner then Metformin may be the pill for you.
I told a friend about this drug's life-extension possibilities. We set out to meet at Starbucks but, prior to leaving, he took 2 x 500-mg Metformin (he's a diabetic and so has a prescription). An hour later he arrived and confessed that his tardiness was incurred when a fart was revealed to contain a lump. He had to return home to change his pants.
Apparently, the TAME trial has gotten FDA approval since 2015, but has yet to be launched as a full fledged clinical trial, apparently because "there is no way in hell to make money on it. So how would we fund a clinical trial? Well, yes, the only way is philanthropic" [2]
[1] https://nutritionfacts.org/video/the-tame-trial-targeting-ag... [2] https://youtu.be/_9I0R8I16XQ?feature=shared&t=105