In the late 1970s, Gordon Moore believed that their next ISA would last the lifetime of the company. Now, technically, he thought their next ISA would be in the 8800. But it was such a drawn out failure they came up with the 8086 in an emergency 3-week sprint.
There always have been vastly more chips of another architecture for every x86 chip. Most of the output of fabs with older processes are microcontrollers, most of which use some bespoke instruction set.
The compiled languages would likely output a single MOV and ADD and get done in 2 cycles (plus any time to fetch from memory). Something like Python probably takes a couple hundred with all its type checking. JIT languages I would think would take a couple hundred the first time the line gets executed, but then have a single MOV and ADD ready the next time, unless I'm completely misunderstanding JIT.
https://www.intel.com/content/www/us/en/developer/articles/t...
Intel dropped support for 16 bit booting with their firmware from a few years ago. And with x86S are looking to drop support all together and push people to virtualization