Had a driverless way make an abrupt left turn in front of me (going opposite direction) on Bayshore a few weeks ago. If it signaled it did so at the last minute. I had to slam on my brakes to avoid broadsiding. They aren’t safe.
The question is not which is perfectly safe because neither is. The question should be which is more safe.
I can't count how many times I was almost either run over or hit while driving by someone who went the wrong way down a one-way street. It got to the point where I had the habit of almost exclusively looking for traffic in the wrong direction when using a crosswalk.