I'd love to see St Louis start to develop a tech startup scene.
Low cost of living, really cool neighborhoods and lots of smart programmers at stodgy big companies. It seems like the city just needs some capital & a few experienced tech entrepreneurs to get it going.
That being said, I don't know of any Wash U CS grads that stayed in St Louis for startups - they all headed for the coasts (me included.) Hopefully that'll change over time.