Compared to Zen4, Zen5 has much higher latency between cores on different chiplets. It's possible that a scheduler + app combo could regress on Zen5 for this reason. It sounds basically impossible for single-threaded apps to be impacted because timeslices are really big. Multithreaded apps where threads are communicating constantly could easily run slower if the scheduler sees all the cores as identical and interchangeable.
I don't know much about this topic, but it seems like Windows uses Processor Groups for scheduling[0], and generally tries to fit each NUMA node into 1 Processor Group (as long as it has at most 64 cores in it). Since the issue here is latency between chiplets and no NUMA is involved, all the cores go in the same Processor Group.
[0]: https://learn.microsoft.com/en-us/windows/win32/procthread/p...