Unlikely unless the Republican Party starts winning the popular vote once in a while. Ronald Reagan was the last Republican president to win the popular vote.
Also of note is that of the five times the popular vote winner did not win, four of those times it was the Republican who won and once it was the more conservative of the two parties (before the Republicans existed).
So yeah, the EC so far has only ever benefited the Conservative Party.
A Lincoln Party or some other new, reformed, conservative party of integrity would stand a chance however—something I welcome, though I would not vote that way.