For example - Several of my close friends are trans. For the last decade or so, Republicans have been viciously attacking trans people and several states are actively taking away their rights. The entire right wing media ecosystem uses every chance they can to demonize trans people in the new culture war.
After years of these horrible attacks, we're seeing hate crimes against trans people rise. At least two of my friends have been assaulted in the last year or so.
How can I fault them for having a gut reaction to not engage with Republicans? And if someone is still happy to call themselves a Republican after all this hate, I think that reflects something about their character. Obviously if I were to vote for Republicans who want to hurt my trans friends (which is almost all of them), I could never look them in the eyes again. Similarly, I can't have much respect for those who do. The life and safety of my friends and family is the most important thing to me.
I am happy to engage in good faith dialogue with conservatives on these topics, but frankly, if I'm out and doing something I enjoy, I'd generally rather not spoil my time talking to someone who is statistically likely to be a hateful bigot.