In fact, the most effective anti-piracy software development strategy is the simplest one of all:
1. Have a great freaking product.
2. Charge a fair price for it.
Is he joking? The World of Goo is a great freaking product. And The World of Goo is fairly priced at $20. And yet the piracy rate is still at 82% or so. So where does Jeff base his "in fact" anti-piracy claim on?