Also, I found that L-Theanine helped but only for maybe a week or so before it became less and less effective. For me, it was obviously a band-aid solution that wasn't correcting the underlying problem.
EDIT: It would seem that the vitamin C paper [1] concludes the opposite of what [0] states. "These results indicate that the elimination of caffeine in the elderly is not affected significantly by the concentrations of vitamin C achieved during this study."
[0] https://www.coffeeandscience.org/health/coffee-and-caffeine/caffeine-and-metabolism
[1] https://pubmed.ncbi.nlm.nih.gov/7064899/"Caffeine metabolism is increased by smoking, an effect mediated by an acceleration in its demethylation (it also increases xanthine oxidase activity) (Parsons and Neims, 1978). Smoking cessation returns caffeine clearance rates to nonsmoking values (Murphy et al., 1988)."
https://www.ncbi.nlm.nih.gov/books/NBK223808/#:~:text=Caffei....
Caffeine is a purine (https://en.wikipedia.org/wiki/Caffeine).
A Google Scholar search for "molybdenum purine" will come up with many studies discussing how molybdenum is involved in purine catabolism. For example, the following article states "[molybdenum] is considered essential because it is part of a complex called molybdenum cofactor that is required for the three mammalian enzymes xanthine oxidase (XO), aldehyde oxidase (AO), and sulfite oxidase (SO). XO participates in the metabolism of purines". (https://aspenjournals.onlinelibrary.wiley.com/doi/abs/10.117...).
When I was younger I was able to drink multiple pots of coffee in a day and even drink coffee right before going to sleep without any obvious issues. So when I couldn't even drink a single cup of coffee in the morning on a regular basis without problems I had reason to believe there was something wrong with me and it wasn't simply a genetic quirk.
If those above are to be believed (or not suffering a psychosomatic response) and are still affected by decaffeinated coffee then the dosage between different individuals for given psychotropic effects to occur could be as high as 100:1.
As someone who can drink copious nubmers of cups of coffee in a single sitting and notice very little effect I'm curious to know why this range is so wide (heaven help patients, doctors and pharmaceutical manufacturers if all drugs had such a wide range).
Whenever I raise this the common retort is that I've developed a tolerance to caffeine, and no doubt that's true to some extent. But from experience it's pretty limited, I've been in situations where I've not had caffeinated drinks for months and not noticed any difference when I returned to them. Also, decades ago when I was a student I took up coffee to help stay awake whilst studying and it was pretty inefective. I tried evey strong brew availabe including up to five heaped teaspoons of Moccona instant coffee per cup and it was like water off a duck's back—almost useless/inefective.
The question is why do some people have a supersensitive response to caffeine whilst others do not.
Another consideration is that people seem to often report that coffee is more stimulating than caffeine pills, even if the amount of caffeine is similar.
OK, that makes sense and I'm not surprised. I claim no expertise in coffee chemistry but I'd guess there'd likely be small amounts of other xanthines including xanthine, theophyline, theobromine [we ought to stop using that confusing name] and perhaps others. Are you referring to these or another class of drugs altogether?
You know, your mention that others report coffee more stimulating than caffeine pills got me thinking. As I said in my other comment, caffeine did little for me when I was studying, heaps of instant coffee made very little difference. I'd not mentioned it but I'd also tried OTC caffeine pills and they were pretty useless (and instant coffee was cheaper).
Now to an interesting connection you've just reminded me of. Some years after I'd finished studying (trying to stay awake with caffeine), we used to frequent a little French restaurant that served an unusual type of coffee that I enjoyed very much.
Being a frequent customer I asked the owner what type of coffee he was serving and he told me it was a special New Guinea blend that he'd specifically selected for the restaurant.
Now to the interesting part: as I said, many cups of caffeine-laden coffee have little effect on me but this coffee was something else altogether. Within a short time of consuming a cup or two I'd get a sudden urge to urinate, similarly my partner and the coffee had an even stronger effect on her than it did me. This wasn't an isolated case, it happened whenever we went to the restaurant, in fact we used to joke about it.
I need to add that I've always had a pretty good bladder, for example I've crossed the Pacific from Los Angeles to Sydney numbers of times without needing to use the restroom. So there was something rather unusual about that coffee. It's only a guess but I'd reckon it likely had much more than the usual trace of theophyline in it. Perhaps there were much higher levels other xanthines as well.
Hum, now I'm wondering whether these methylxanthines can act synergistically when in certain combinations/ratios. If it wasn't one or more of them in combination in that coffee then I wonder what other drug could have caused the strong diuretic effect.
Thanks for you point, it's made me think.
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383091 (2) http://medical-technologies.eu/upload/1.effects_of_coffee_al... (3) https://www.sciencedirect.com/science/article/pii/S030881460...
However, I've already noted in (2) a statement under Theobromine that it's a strong diuretic. That's interesting but what does strong mean here? I dislike simple-notion words in papers unless they're quantified (they require numbers against them).
That said, that's not a criticism of the paper having just glanced at it, and it has lots of other interesting stuff I'll need to read in detail. What's particularly relevant about the theobromine entry is this mention of the molecule's strong diuretic effect. When I made my point towards the end of my comment that that particular coffee 'likely had much more than the usual trace of theophyline in it', I deliberately left out reference to theobromine because I'd seen references that it was biologically less active than either theophyline and caffeine.
What was implied was that when evaluating the effects of coffee that theobromine was essentially considered irrelevant because it wasn't as biologically potent as either theophyline and caffeine and that its concentration in coffee is considerably lower than either of the other two.
Perhaps the earlier reference (which I've to locate again) was referring to theobromine's psychotropic effects rather than its diuretic effects. I'll now have to review and revise my understanding of common xanthines to correct my misunderstandings.
As someone who's not professionally involved in this field I sometimes think I'm a little mad for allowing my curiosity to get the better of me. :-)
Did you have blood markers checked? For me, some values like GPT/GGT are in fact increased for unknown reasons.
I recently and unsuccessfuly researched ways to participate in studies, as I'd like to understand why I can't eat chocolate or drink coffee anymore.. I'm slightly concerned other toxins wouldn't be metabolized as well either, leading to early cancer down the road.
When I was sensitive to coffee I felt just wrecked and exhausted by the coffee. I couldn't sleep well at night. Several days in a row of drinking one coffee in the morning and I'd get to the point where I would wake up feeling jittery the next day. Now, this is completely resolved.
My blood tests for commonly tested health markers such GPT and GGT have always been fine and tend to be tested about once a year. I had the coffee sensitivity for quite a few years until recently when I finally resolved it.
I do have some minor gut issues, so I'm guessing this is to blame for any nutritional deficiencies (I eat a healthy diet of "real" food).
These days I'm limiting my intake to once a month or so
So definitely don't overdo it on the cacao and eat hundreds of grams per day, but IMO no reason to avoid it completely, relative to other vegetables that can accumulate cadmium. This is not medical or dietary advice.
Do you mean choco-nibs? love these, and they are great for adding crunch to things.
You didn't really quit caffeine, you lowered intake.
I have an unusually strong response to caffeine (a cup of coffee, strong tea, or, on a bad day, even a small glass of Coke). It doesn't really affect my heart (as far as my Apple Watch can tell), but it obliterates my sleep and makes me feel quite a bit more anxious than usual. Decaf coffee solves the problem completely — no stimulation, no anxiety, normal sleep. Coincidentally, I had a tall glass of iced decaf just two hours ago, and I'm going to bed in a few minutes.
I'm equally sensitive to alcohol. Because it's immediately absorbed into the blood, a sip of scotch will take out my antidepressant in seconds. It's shocking how quickly and how severely even a small amount of alcohol affects me. It's almost like an allergy.