http://paulgraham.com/ideas.html
http://ycombinator.com/ideas.html
http://paulgraham.com/ambitious.html
http://www.quora.com/Startup-Ideas/As-of-2012-what-are-some-...
If I had to recommend one area to explore, I'd say something to do with lightweight, portable electrical power. As handheld and portable computing devices proliferate, battery life and recharging shenanigans are becoming more and more obnoxious. Especially at airports like O'Hare where electrical outlets are in short supply. A breakthrough in fuel cell technology or something of that nature would be nice.
Also, anything based on allowing people to self-organize into groups for mutual purposes, in such a way as to reduce (or eliminate) the status of "government" as-we-know-it as the default mechanism for communal / collective initiatives.