> Multi-domain genies like Goethe, Da Vinci (, Jobs, Feynman?)
I'm sorry but I just can't let this go without comment.
Steve Jobs was not a "multi-domain genius." He had a single, very specific genius, namely gathering lots and lots of ideas and picking the very best one. (IMO the fact that he was an asshole is probably related but not essential.) His entire career was applying this single ability, which he really was a genius of, to multiple domains. He wasn't a genius at anything about those domains per se, just at what he did once he was working in them. I mean, the fact that he had any technical knowledge at all about operating systems or computer graphics already put him in the top tier of "business guys" but that's not the same thing as a deep understanding.
For that matter, let's keep going on your list. Richard Feynmann was a smart guy but all his important work (except superfluidity in helium, I guess) was made exploring a single theme, namely how to put quantum mechanics in a Lagrangian formulation rather than a Hamiltonian. He told the story once of the event that sparked his first interest in physics as a career, and it was his high school physics teacher taking him aside and explaining the principle of least action (the basis of the Lagrangian formulation of classical mechanics) - he basically organized the rest of his career around understanding this principle very, very deeply. The reason he's famous in addition to being smart is that he found a new domain to apply it to, namely quantum mechanics.
My point is that while mastering a domain of application was important for these people, probably even crucial, it wasn't really the engine of their success. They first developed a single talent or interest, and then looked for a domain to apply it to.