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Cool it with your moral authority.
You may need a "study" to believe it, but I no longer do..
I enjoy psychedelics, but I am also aware of the potential risks because I've seen them. I don't pretend that incidents don't happen just because they are rare, and because I enjoy them.
I was acquaintanced with a guy who had safely taken significant amounts of shrooms for years (he asserts more therapeutic reasons than recreational), having slowly tested up to ~5grams, so was seemingly in the clear are far as uncovering schizophrenia and the like. Then he took a bit more one day, he estimates about 7grams, and basically his connection with his sense of body and presence in the world became severed. Described it like being dead, but trapped in a body, unable to feel joy or relationships. This persisted for 3 years despite many attempts to resolve it. In the end he committed suicide.
While things like microdosing are definitely intriguing, my own exploration on the topic and reading many accounts has left me with the strong impression that for psilocybin, any dosage above 3grams (of dry Psilocybe cubensis) poses an unacceptable risk of negative outcomes.
As such, I strongly caution against naive exploration, and stay the hell away from higher doses. Especially since those seeking psychedelics as a treatment are much more likely to have multiple issues that increase the likelihood of severely negative outcomes. Users should also be aware that under elevated doses, self harm or harm to others becomes possible. Assaults, murders, and suicides under the influence are a reality that cannot morally just be ignored.
Which brings up another point; in general the psychedelic communities online that I’ve observed do not generally appreciate the mention of bad outcomes, to the point where they actively censor things as anti-psychedelic conspiracy. That coupled with problems in getting accurate medical data make it hard to tell the actual rate of severely negative outcomes. Those who take psychedelics have a vested interest in seeing only the good outcomes.
I must ask, is this based on scientific evidence?
The result being that processing emotions and making key realizations actually “stick”. It’s possible for example as someone who suffers from PTSD to realize that it’s no longer necessary to be on high alert, but the body is anyway.
I’m also no expert so take this with a grain of salt, but I think it’s less of a defragmentation and more of an increase in pliability that leads to lasting changes.
This is one of the reasons that Psylocibin-assisted therapy is showing such promising results. The brain entering that state unguided may or may not lead to good results. But when a trained therapist is involved, outcomes improve.
I'm not sure it could be correctly stated in the gross sense as "jumbling it up and making it re-build," but there certainly is a shift in how the brain's components work together for the duration of the drug's effects, per this study.