Fascinating stuff, it's interesting to read that the main ligands of the AhR (Aryl hydrocarbon receptor) are PAHs (Polycyclic aromatic hydrocarbons) and that activation of the AhR receptor improves the markers of Lupus.

Polycyclic aromatic hydrocarbons are nasty, carcinogenic, molecules that are commonly found in smoke, tar, and char. Basically burnt organic matter. On the other side of the coin AhR is also activated by a bunch of Polyphenols, which are found in a variety of plant derived foods.

Does this mean, it is possible that Lupus (and Psoriasis) are diseases of affluence caused by processed food (low in Polyphenols), and a reduced exposure to smoke byproducts in the environment?