I think the budgets required would make any of the things you describe as flagship missions. Taking years after launch before the mission can start is a hard sell. The couple of months for JWST to become operational seemed like it was killing some anxious/excited people in that wait. Nevermind the decades long wait from delays in getting it launched too. It could literally something where the designers/builders never see the results. So I guess we should have started 10 years ago?
There are also observations which extend beyond the electromagnetic spectrum itself, or sample physical conditions in the neighbourhood of outer-solar-system planets.
(These are not knocks on JWST which is absolutely phenomenal for what it does. These are simply observations on the limits of JWST or any comparable near-Earth telescope or remote-sensing resources.)
Also, JWST is mostly looking at things kind far away and sort of a long time ago (with some closer that is incredible. It cannot really compare to the images from Voyager(s) of the outer planets.