I think another cause could be bureaucratic. From what I understand, several hundred years ago, research was funded by rich patrons who wanted some credit in relation to discoveries. Nowadays there is a giant, lurking, centrally planned grant machine that distributes money to researchers. And as we know from economics, central planning becomes increasingly untenable as the system becomes larger. Results get worse as the complexity skyrockets.
Additionally, if we are going to blame the “burden of knowledge” in any capacity, we have to acknowledge the abysmal education system (in the US). An anecdote which I will never forget is, in 6th grade we had a student who had recently immigrated from India. By his own telling, he was an average student there. But compared to native students, he was light years ahead in math. We learned multiplication in third grade, division in fourth grade, long division and fractions in fifth grade, or something like that. He had learned multiplication in first grade, and all of division in second grade. While our smartest students in sixth grade were grappling with pre algebra, he was bored in classes with the eighth grade algebra students. Our education system has, since experiencing that, seemed to me deeply flawed; there really is no reason an efficient and effective public education system should take 12+ years to be able to have a child ready for college and then another 4+ in college to have them ready to contribute to an isolated field.